Human Protein Complex Map

Proteins interact with each other and organize themselves into macromolecular machines (ie. complexes) to carry out essential functions of the cell. We have a good understanding of a few complexes such as the proteasome and the ribosome but currently we have an incomplete view of all protein complexes as well as their functions. The hu.MAP attempts to address this lack of understanding by integrating several large scale protein interaction datasets to obtain the most comprehensive view of protein complexes. Specifically, we integrated two large scale affinity purification mass spectrometry (AP/MS) datasets from Bioplex and Hein et al. with our dataset of large scale biochemical fractionations (Wan et al) and produced a complex map with over 4k complexes.


  Kevin Drew (website)
  Edward Marcotte (website)


  NIH F32 GM112495




  proteincomplexmap (at)